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Fellowship to be set up in memory of pioneering liver transplant surgeon, Professor Sir Roy Calne

Addenbrooke’s Charitable Trust is delighted to be creating a Fellowship in memory of one of the world’s leading transplant pioneers, Professor Sir Roy Calne.

Sir Roy performed the first successful liver transplant in Europe at Addenbrooke’s on 2 May 1968, and dedicated his life to turning seemingly impossible surgery into regular practice at Addenbrooke’s, where he had previously established the kidney transplant service.

In 2018, Sir Roy helped launch ACT’s £250,000 appeal to fund a state-of-the art ‘liver perfusion’ machine. This machine helps newly donated livers survive for longer and, crucially, enables surgeons to ‘test-drive’ livers on a system mimicking the body, ensuring their functionality before transplant.

ACT CEO, Shelly Thake, said: “The Fellowship means Sir Roy’s work will live on in his name. He was very keen on the evolution of science, research, and medicine and was a great mentor and teacher to many. What a great opportunity to give people to learn more and to advance science like he did.

“Sir Roy was a great supporter of our charity and understood what an advantage that gave to science through research and our support within the hospitals. Being able to support someone in their research journey seems befitting for his memory.”

The idea for a Fellowship in Sir Roy’s name was first mooted by colleague, Professor John Bradley.

Sir Roy and Professor Watson welcoming the new liver perfusion machine at Addenbrooke’s back in 2019.

Retired Professor of Transplantation, Chris Watson, a former colleague of Sir Roy’s, described the plan to create a fellowship in his name as “a great tribute to him.”

“We are not going to move forward without research and that was highlighted during COVID where research found a treatment for the disease and further research found a vaccine, so research is fundamental to moving forward in medicine.”

“The single research post or succession of research posts we hope to fund through the Fellowship, depending on how much funds we will have, are important in a small way in that they make up parts of a bigger jigsaw of moving medical fields forward. It’s the small steps that make big differences.”

Professor Watson, who first met Sir Roy as a medical student when he attended teaching sessions run by him in Cambridge on Saturday mornings, later worked with him during his time as both a Registrar and Senior Registrar, as well as during his three-year-research project looking at tolerance in transplantation using Monoclonal Antibodies.

“He was a very good teacher. He was someone who would challenge you to think and he was quite entertaining and amusing at times. And he came in on a Saturday morning, which says a lot. It’s quite impressive really.”

If you would like to give a gift dedicated to the memory of Sir Roy Calne to set up a new Research Fellowship in his name through ACT, visit https://professorsirroycalne.muchloved.com/

Addenbrooke’s liver transplant appeal success gives precious hope to many

Addenbrooke’s Charitable Trust (ACT) has reached its £250,000 liver transplant appeal target thanks to the generous support of incredible donors.

The charity wanted to invest in the latest technology to give patients at Addenbrooke’s the best care possible by fundraising for a new liver perfusion machine in 2018. Liver perfusion is a system mimicking the body to ensure a liver’s functionality before transplant. The equipment has now been fully funded, and allows surgeons to ‘test drive’ livers for suitability before transplanting them.

Since the installation of the liver perfusion machine – the first hospital in the UK which has one in routine use for transplants – the Transplant team at Addenbrooke’s have perfused a total of 57 livers, of which 43 were able to be used. This means that the lives of 43 more people have been saved, taking them off the waiting list and enabling them to spend many more years with their loved ones.

Paul Wren was placed on the liver transplant list in 2017. In January 2018, he received a call to say that a liver was ready for him. He travelled down to Addenbrooke’s only to discover that, unfortunately, the liver was not suitable. After this stressful false alarm, Paul was called again in August by the Transplant team who had another liver for him. This time, the liver perfusion machine was in operation. As a result, the suitability of the liver was tested and confirmed for use, and Paul finally received his transplant.

Professor Christopher Watson, Consultant Transplant Surgeon at Addenbrooke’s, said: “Having the machine allows Addenbrooke’s to use the greatest proportion of high risk livers (those where subsequent function would otherwise be uncertain) than any other transplant centre in the UK; it also contributes to our having the best 30-day survival rate and the highest transplant rate per waiting list patient, meaning that fewer patients will die waiting for a liver.”

As more transplants are being carried out –  as well as the forthcoming opt-out system for organ donation – ACT wants to ensure that the hospital is ready for this increased demand. The charity would now like to support improvements that will ensure that patients and the relatives visiting them in hospital are more comfortable, such as making our patient day rooms more homely as well as providing a brighter, more comfortable space for patients being assessed for a liver transplant.

If you would like to make the above improvements a reality for transplant patients, please donate online at www.act4addenbrookes.org.uk/donate and choose ‘Transplant’ when prompted.

Find more about our Transplant campaign here.